.NET 4.6 might cause unpatched Service Bus 1.1 for Windows server to become unresponsive
After the Microsoft .NET Framework 4.6 or a product that includes the .NET Framework 4.6, such as Visual Studio 2015, is installed, Service Bus for Windows Server 1.1 is unresponsive. The services may not start. Or if the services do start, they do not respond to client requests.
There is a hotfix available from Microsoft that addresses this issue. See the following KB from Microsoft for more information: https://support.microsoft.com/en-us/kb/3086798